基于工程状态标定的诊断载荷试验识别方法及应用

针对在役公路梁式桥梁由于材料性能退化及外部环境等因素共同作用而导致承载力不足、耐久性降低等问题,开展旧桥力学性能的快速诊断试验研究。通过诊断性载荷试验的理论分析和有限元模型标定流程研究,快速、高效地完成在役公路桥梁的承载力性能测量和评估,从而为在役公路桥梁结构的养护管理提供可靠的技术支持。     

木片筛余物高得率半化学法清洁制浆技术研究

以太阳纸业备料车间木片筛选碎料（筛余物）为原料，对其烧碱法半化学制浆的实验室工艺和生产试验进行了研究。结果表明，筛余物采用半化学法制浆可获得较高得率和环压强度的纸浆，且用碱量对纸浆性能有显著影响。相对8%NaOH （相对于绝干原料）化学预处理，采用14%NaOH化学预处理结合两段浆浓22%的高浓磨浆工艺，所制半化学浆抄造浆张的裂断长和环压指数分别达2.89 km和9.76 N·m/g，是前者的1.9倍和1.2倍，而且优于现用国内OCC废纸浆抄造浆张；生产试验得到的浆张性能指标与实验室相吻合，其中紧度和环压强度分别达到GB/T 13023—2008瓦楞芯（原）纸AA级和A级优等品要求。     

生物质源多孔碳制备及其对废水中药物吸附研究进展

城市现代化与工业化的快速发展给环境造成的污染日趋严重，尤其以水体污染最为明显。近年来，工业废水中药物的含量逐年上升，污染程度已经不容忽视。因此，开发新型多孔材料用于废水中药物分子的吸附分离，已经成为了当前的研究热点。综述了近年来生物质源多孔碳（生物炭）在废水中污染物吸附分离方面的研究，首先简单介绍了废水中污染物的治理方法，在此基础上重点探讨了生物炭的制备与修饰，并结合碳材料表面化学性质与孔道结构，总结并展望了生物炭对药物的吸附性能。     

SBR处理村镇生活污水试验研究

研究了用SBR处理系统在不同水力停留时间,不同污泥龄(SRT),不同温度条件下对村镇生活污水的去除有机物、脱氮除磷效果。结果表明,考虑到脱氮除磷效果并兼顾经济的原则,水力停留时间采用6h比较合理,SBR反应器的最适SRT为20d;温度SBR反应器的除磷效果影响较小,SBR反应器更适合处理低温污水。     

基于连续介质损伤力学的7075铝合金高温成形极限理论预测与数值仿真

开展7075铝合金高温单向拉伸试验和成形极限试验，获得了不同温度和应变率的应力-应变曲线和成形极限曲线。结果表明，在较高的温度和应变率时7075铝合金的强度减小、成形性提高。为描述7075铝合金高温损伤演化过程，提出一种改进的连续介质损伤模型，并建立了耦合损伤的多轴统一黏塑性本构模型。基于试验结果，运用NSGAII遗传算法标定了模型中的参数，标定后的本构模型可以很好地预测7075铝合金的高温热力行为和极限应变。通过有限元软件Abaqus的用户材料子程序VUMAT，该本构模型被编入到Abaqus软件中进行数值仿真计算。结果表明，仿真获得的成形极限曲线和应变场分布与试验和理论结果吻合度好，进一步证明了所建立的耦合损伤的多轴本构模型的正确性及其在高温成形极限有限元仿真中的适用性。     

Decreased CD10-positive granulocytes for the differential diagnosis of myelodysplastic syndrome

Myelodysplastic syndromes (MDS) are highly heterogeneous myeloid neoplasms, and a large number of patients are difficult to diagnose and classify by blood and bone marrow examination. As a surface marker of granulocyte, studies have shown CD10 can be used to define the degree of granulocyte maturation in MDS patients. However, whether it can be used for differential diagnosis of MDS and other hematological diseases remains inconclusive. To explore the value of CD10 for differential diagnosis of MDS, 60 newly diagnosed MDS, 20 aplastic anemia (AA) patients, and 35 iron-deficient anemia (IDA) patients were selected for this study. Bone marrow (BM) specimens were processed for surface marker analysis and labeled with pre-conjugated monoclonal antibodies. Stained cells were detected by flow cytometry. Our results indicated that CD10-positive granulocytes were significantly decreased in BM of MDS patients than AA and IDA patients, and the level of CD10-positive mature granulocytes was not associated with the clinical stages of malignancy. Receiver operating characteristic (ROC) areas under the curve (AUC) of CD10-positive granulocytes was 0.86 and 0.85, respectively, in MDS patients than the IDA group and AA group with good specificity and sensitivity. Further, CD10-positive granulocytes were increased after effective treatment. In conclusion, we found the decrease in CD10-positive granulocytes has a differential diagnostic value of MDS.     

土壤污染的电动-可渗透反应墙联合修复技术研究进展

基于我国土壤污染现状介绍了一种新兴的土壤原位修复技术,即电动-可渗透反应墙(EK-PRB)联合修复技术,阐述了其原理简单易行、应用范围广并存在潜在应用价值的特点,重点叙述了EK-PRB联合修复污染土壤技术的研究与应用进展。进一步归纳了该技术的优势与不足,结合实际土壤修复的特点及我国的具体情况指出EK-PRB联合修复技术在土壤修复领域的发展方向,进而提出该技术在实际应用中的发展趋势。     

Effect of Peroxiredoxin 1 on the biological function of airway epithelial cells and epithelial-mesenchymal transition

Peroxiredoxin 1 (PRDX1) participates in tumor cell proliferation, apoptosis, migration, invasion, and the epithelial-to-mesenchymal transition (EMT). This study aimed to investigate the effect of PRDX1 on the EMT of airway epithelial cells stimulated with lipopolysaccharide (LPS) and transforming growth factor-beta 1 (TGF-β1). PRDX1 overexpression significantly increased the proliferation and migration of human bronchial epithelial (BEAS-2B) cells, reduced cell apoptosis (p < 0.01), and induced EMT and collagen deposition by upregulating the expression of the matrix metallopeptidase (MMP)2, MMP9, α-smooth muscle actin (α-SMA), N-cadherin, vimentin and twist proteins and inhibiting E-cadherin expression (p < 0.05). PRDX1 overexpression promoted TGF-β1-mediated inhibition of cell proliferation and migration and significantly enhanced the TGF-β1-induced EMT and collagen synthesis (p < 0.05). Knockdown of PRDX1 inhibited cell proliferation, migration, EMT, and collagen synthesis (p < 0.01), reversed LPS-mediated inhibition of cell proliferation and migration, and significantly suppressed LPS-induced EMT and collagen synthesis (p < 0.01). The result indicating that PRDX1 may be involved in LPS/TGF-1-induced EMT and collagen synthesis in human bronchial epithelial cells.     

TBP-TEVA萃取色层分离-α能谱法测定辐照镎靶溶解液中痕量236Pu的可行性

²³⁶Pu的含量控制是钚热源的一项重要参数，通过α能谱准确测量镎靶溶解液中痕量²³⁶Pu，建立镎靶辐照靶件溶解液中钚的分离方法。根据杂质组成特点采用TBP-TEVA萃取色层双柱分离，用氨基磺酸亚铁以及亚硝酸钠对钚进行调价，对靶件溶解液中的Al、Fe、U、Th和Np等进行分离，去污系数均大于10⁴，钚的回收率为90.7%。研究大量²³⁸Pu对α能谱测定²³⁶Pu的干扰，结果表明，大量²³⁸Pu会造成仪器本底升高，²³⁸Pu能谱峰分辨率降低；在7 500 Bq ²³⁸Pu干扰下，测量4.3 h 时，²³⁶Pu的最小可检测活度为1.20×10^-2 Bq（当量质量为6.11×10^-16 g）。计算结果表明，镎靶溶解液样品中钚的同位素比值n(²³⁶Pu)/n(²³⁸Pu) ≥4.63×10^-8时，取合适的样品量使得电沉积源中²³⁸Pu 活度在 450~7 500 Bq范围内，均可测量其中的痕量²³⁶Pu，同时可准确测定同位素比值n(²³⁶Pu)/n(²³⁸Pu)。